اثرات آلومینیوم بر غلظت آنزیمهای ALT,AST,LDH

The effect of aluminium on serum parameters related to liver function was investigated over different period of times. Serum lactate Dehydrogenase (LDH), Aspartate aminotrans­ferase (AST), Alanin aminotransferase (ALT) and total protein were chosen as indexes for liver function. Daily intraperitoneal administ­ration of 185 umoleslkg aluminium for 35 days elevated serum aluminium concentration from 10±0.5 to 668±81 f.lg/L. Short term administration of 740 umoleslkg of aluminium daily for 10 days elevated LDH, AST, ALT and bilirubin concentrations by 27%, 18%, 62% and 60% respectively in comparison to controls. Daily administration of 35, 185 and 370 umoleslkg of aluminium for 60 days elevated serum levels of LDH (33%, 47% and 69%), AST (29%, 34% and 70%), ALT (31%, 39% and 77%) and bilirubin (26% , 36% and 41%) respectively. Protein concentration was elevated significantly. Aluminium administration might disturb liver function by interferring with biochemical pathways. The interference of aluminium with parameters related to liver function has been discussed here.